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Author Topic: Canola oil linked to worsened memory and learning ability in Alzheimer's  (Read 141 times)

Online astr0144

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Canola oil linked to worsened memory and learning ability in Alzheimer's

Not as yet investigated in any detail...but I wonder if Anyone been aware of the dangers of certain Vegetable Oils..or what other names they may come under if its a type of Canola Oil or other Veg Oils that we need to be aware about..

I assume some of the danger oils are more than likely created from GMO or similar type crops.

Since it was suggested that cooking Oils were better to use healthwise than say using butter or lard, like many used over say 20 years ago...

I wonder how that is viewed now.. if many Veg Oils are GMO related..

some people still claim they use Butter or lard and are still healthy and well mentally from using them..



Domenico Praticò, MD, Professor in the Departments of Pharmacology and Microbiology and Director of the Alzheimer's Center at the Lewis Katz School of Medicine at Temple University, as well as senior investigator on the study. Credit: Lewis Katz School of Medicine at Temple University

Canola oil is one of the most widely consumed vegetable oils in the world, yet surprisingly little is known about its effects on health. Now, a new study published online December 7 in the journal Scientific Reports by researchers at the Lewis Katz School of Medicine at Temple University (LKSOM) associates the consumption of canola oil in the diet with worsened memory, worsened learning ability and weight gain in mice which model Alzheimer's disease. The study is the first to suggest that canola oil is more harmful than healthful for the brain.

"Canola oil is appealing because it is less expensive than other vegetable oils, and it is advertised as being healthy," explained Domenico Praticò, MD, Professor in the Departments of Pharmacology and Microbiology and Director of the Alzheimer's Center at LKSOM, as well as senior investigator on the study. "Very few studies, however, have examined that claim, especially in terms of the brain."

Curious about how canola oil affects brain function, Dr. Praticò and Elisabetta Lauretti, a graduate student in Dr. Pratico's laboratory at LKSOM and co-author on the new study, focused their work on memory impairment and the formation of amyloid plaques and neurofibrillary tangles in an Alzheimer's disease mouse model. Amyloid plaques and phosphorylated tau, which is responsible for the formation of tau neurofibrillary tangles, contribute to neuronal dysfunction and degeneration and memory loss in Alzheimer's disease. The animal model was designed to recapitulate Alzheimer's in humans, progressing from an asymptomatic phase in early life to full-blown disease in aged animals.

Dr. Praticò and Lauretti had previously used the same mouse model in an investigation of olive oil, the results of which were published earlier in 2017. In that study, they found that Alzheimer mice fed a diet enriched with extra-virgin olive oil had reduced levels of amyloid plaques and phosphorylated tau and experienced memory improvement. For their latest work, they wanted to determine whether canola oil is similarly beneficial for the brain.

The researchers started by dividing the mice into two groups at six months of age, before the animals developed signs of Alzheimer's disease. One group was fed a normal diet, while the other was fed a diet supplemented with the equivalent of about two tablespoons of canola oil daily.

The researchers then assessed the animals at 12 months. One of the first differences observed was in body weight - animals on the canola oil-enriched diet weighed significantly more than mice on the regular diet. Maze tests to assess working memory, short-term memory, and learning ability uncovered additional differences. Most significantly, mice that had consumed canola oil over a period of six months suffered impairments in working memory.

Examination of brain tissue from the two groups of mice revealed that canola oil-treated animals had greatly reduced levels of amyloid beta 1-40. Amyloid beta 1-40 is the more soluble form of the amyloid beta proteins. It generally is considered to serve a beneficial role in the brain and acts as a buffer for the more harmful insoluble form, amyloid beta 1-42.

As a result of decreased amyloid beta 1-40, animals on the canola oil diet further showed increased formation of amyloid plaques in the brain, with neurons engulfed in amyloid beta 1-42. The damage was accompanied by a significant decrease in the number of contacts between neurons, indicative of extensive synapse injury. Synapses, the areas where neurons come into contact with one another, play a central role in memory formation and retrieval.

"Amyloid beta 1-40 neutralizes the actions of amyloid 1-42, which means that a decrease in 1-40, like the one observed in our study, leaves 1-42 unchecked," Dr. Praticò explained. "In our model, this change in ratio resulted in considerable neuronal damage, decreased neural contacts, and memory impairment."

The findings suggest that long-term consumption of canola oil is not beneficial to brain health. "Even though canola oil is a vegetable oil, we need to be careful before we say that it is healthy," Dr. Praticò said. "Based on the evidence from this study, canola oil should not be thought of as being equivalent to oils with proven health benefits."

The next step is to carry out a study of shorter duration to determine the minimum extent of exposure necessary to produce observable changes in the ratio of amyloid beta 1-42 to 1-40 in the brain and alter synapse connections. A longer study may be warranted in order to determine whether canola oil also eventually impacts tau phosphorylation, since no effects on tau were observed over the six-month exposure period.

"We also want to know whether the negative effects of canola oil are specific for Alzheimer's disease," Dr. Praticò added. "There is a chance that the consumption of canola oil could also affect the onset and course of other neurodegenerative diseases or other forms of dementia."

https://medicalxpress.com/news/2017-12-canola-oil-linked-worsened-memory.html

« Last Edit: December 07, 2017, 07:33:43 PM by astr0144 »

Offline ArMaP

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Re: Canola oil linked to worsened memory and learning ability in Alzheimer's
« Reply #1 on: December 08, 2017, 06:26:01 AM »
I assume some of the danger oils are more than likely created from GMO or similar type crops.
From what I have seen, the problems appear mostly when processing the oil, as the natural oil has to be processed to achieve the low acid content. That happens with other oils.

I looked at what we use in our cooking (a product that is like liquid margarine) and it has sunflower, colza and linseed oils. We also use olive oil, and that has only the problem with the price. :)

Offline space otter

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Re: Canola oil linked to worsened memory and learning ability in Alzheimer's
« Reply #2 on: December 08, 2017, 08:45:52 AM »


i'm not going pro or con here but suggest

always checking on the affiliation of those doing the research and who pays them and who benefits from their so called 'conclusions"

i worked in research for a dozen years and sometimes the 'research' was to back up a sales product almost ready for market
or fill in the background of a foregone conclusion..

look beyond the curtain...

Offline Shasta56

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Re: Canola oil linked to worsened memory and learning ability in Alzheimer's
« Reply #3 on: December 08, 2017, 06:37:01 PM »
Pharmaceutical companies push approvals through based on what they decide a new medication will do.  Then the stuff gets recalled because  it kills people.  But the United States can't have things that  have  been  used in Europe for years, because it hasn't  been  adequately  tested.  I heard all about that in pharmacy  tech school.

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Online astr0144

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Re: Canola oil linked to worsened memory and learning ability in Alzheimer's
« Reply #4 on: December 11, 2017, 05:09:09 PM »
Yes , I think there are quite a few alternatives that would be a safer bet than the cheaper or common chosen type cooking oils sold in the major Supermarkets..

I am not sure if they are classed as NON GMO ...

such as Sunflower or Olive Oil... would they be crop type  products unlikely to be grown or made from a GMO type crop ?

ArMaP
Quote
I looked at what we use in our cooking (a product that is like liquid margarine) and it has sunflower, colza and linseed oils. We also use olive oil, and that has only the problem with the price. :)

That is interesting to know that you had worked in Research S.Otter... I was not aware that you had a actual background in it... BUT that explains why your one of the major posters on PRC and one of the main researchers..

space otter
Quote
i worked in research for a dozen years and sometimes the 'research' was to back up a sales product almost ready for market
or fill in the background of a foregone conclusion..

look beyond the curtain...

Im not sure if what you refer to applies to foods as well as Pharmaceutical Drug type Products Shasta..probably so..

In this case I am referring to Cooking Oils which I would see as a food related product.and maybe Canola is more a USA based crop based Oil, I am not sure..

but say there is a product been in use in the UK for some years..that we would think was safe... Some may think this would give it crediblity to then be sold in other Countries...

Are you saying that the USA would still want to test it to their standards before accepting it ?

The only issue with certain products is that we are aware many are either GMO type or listed in the Builderberg group..
and we know that many of their products are a concern, yet they get accepted and sold in other Countries all over..

Shasta56
Quote
Pharmaceutical companies push approvals through based on what they decide a new medication will do.  Then the stuff gets recalled because  it kills people.  But the United States can't have things that  have  been  used in Europe for years, because it hasn't  been  adequately  tested.  I heard all about that in pharmacy  tech school.



 


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