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Author Topic: Medical Cannabis Comes Through  (Read 1935 times)

Offline WhatTheHey

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Medical Cannabis Comes Through
« on: May 01, 2019, 09:05:44 pm »
  :)  The Cannabis derivative known as CBD or cannabidiol has been coming through test with very beneficial results for children with severe types of epilepsy.  It's also working for people of all ages.    :)

  "Taking a pharmaceutical formulation of cannabidiol, a cannabis-based medicine, cut seizures nearly in half for children with a rare and severe type of epilepsy called Dravet syndrome, according to a phase 3 study released today that will be presented at the American Academy of Neurology's 71st Annual Meeting in Philadelphia, May 4 to 10, 2019. Dravet syndrome, which starts in infancy, can lead to intellectual disability and frequent, prolonged seizures. Cannabidiol is derived from marijuana that does not include the psychoactive part of the plant that creates a "high."

"It's exciting to be able to offer another alternative for children with this debilitating form of epilepsy and their families," said study author Ian Miller, MD, of Nicklaus Children's Hospital, formerly Miami Children's Hospital, in Florida. "The children in this study had already tried an average of four epilepsy drugs with no success and at the time were taking an average of three additional drugs, so to have this measure of success with cannabidiol is a major victory."

The study involved 199 children with an average age of 9 who were divided into three groups. One group received 20 milligrams per kilogram (mg/kg) per day of cannabidiol, the second group received 10 mg/kg per day and the third group received a placebo.

Seizures were recorded for four weeks before the treatments were started to establish a baseline. Then the participants received the treatment for 14 weeks. By the end of the study, seizures with convulsions had decreased for those taking the high dose of the drug by 46 percent and by 49 percent for those taking the lower dose of the drug, compared to 27 percent for those taking the placebo.

Total seizures reduced by 47 percent for those in the high dose group, by 56 percent for those in the lower dose group and by 30 percent for those in the placebo group. In the high dose group, 49 percent of the participants had their seizures cut in half or more, compared to 44 percent in the low dose group and 26 percent in the placebo group.

All of the groups reported side effects, with 90 percent of the high dose group, 88 percent of the low dose group and 89 percent of the placebo group. The most common side effects were decreased appetite, diarrhea, sleepiness, fever and fatigue. About 25 percent of those in the high dose group had serious side effects, compared to 20 percent of those in the low dose group and 15 percent of those in the placebo group. Only participants in the high dose group stopped taking the drug due to side effects; that number was 7 percent.

"Based on these results, dose increases above 10 mg/kg per day should be carefully considered based on the effectiveness and safety for each individual," Miller said.

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American Academy of Neurology. "Cannabis-based medicine may reduce seizures for children with difficult-to-treat epilepsy." ScienceDaily. ScienceDaily, 30 April 2019. <www.sciencedaily.com/releases/2019/04/190430164219.htm>.

    RELATED TOPICS
        Health & Medicine
            Epilepsy Research
            Colon Cancer
            Foodborne Illness
        Mind & Brain
            Epilepsy
            Marijuana
            Child Psychology
        Plants & Animals
            New Species
            Extreme Survival
            Endangered Plants
     RELATED TERMS
        Seizure
        Epilepsy
        Cannabis
        Toxic shock syndrome
        Wound
        Tourette syndrome
        Rett syndrome
        Personalized medicine

RELATED STORIES
Cannabidiol Significantly Reduces Seizures in Patients With Severe Form of Epilepsy
May 16, 2018 — Cannabidiol (CBD), a compound derived from the cannabis plant that does not produce a 'high,' was shown in a new large-scale, randomized, controlled trial to significantly reduce the number ... read more
Cannabidiol Benefits and Mechanisms Shown in Mouse Study of Dravet Syndrome
Oct. 10, 2017 — Cannabidiol, a non-intoxicating derivative from cannabis, has been shown to reduce seizures and autism-like behaviors in a mouse model of a genetic disorder, Dravet syndrome. Children with this ... read more
Cannabidiol Reduces Seizures in Children With Severe Epilepsy
May 26, 2017 — Children with Dravet syndrome, a severe form of epilepsy, had fewer seizures after taking a daily oral solution of the cannabis compound called cannabidiol, which does not have the psychoactive ... read more
Cannabis-Based Medicine May Cut Seizures in Half for Those With Tough-to-Treat Epilepsy
Apr. 18, 2017 — Taking cannabidiol may cut seizures in half for some children and adults with Lennox-Gastaut syndrome (LGS), a severe form of epilepsy, according to new information from a large scale controlled ... read more
FROM AROUND THE WEB
Below are relevant articles that may interest you. ScienceDaily shares links with scholarly publications in the TrendMD network and earns revenue from third-party advertisers, where indicated.

    Cannabidiol Reduces Drop Seizures in Patients With Lennox-Gastaut Syndrome
    Neurology, 2017
    Cannabidiol cuts drop seizure frequency in Lennox-Gastaut syndrome
    Sharon Worcester, Neurology, 2017
    Two Studies Provide Update on Effectiveness of Cannabidiol Derivative in Patients With Epilepsy
    Neurology, 2014
    Two Studies Provide Update on Effectiveness of Cannabidiol Derivative in Patients With Epilepsy
    Neurology, 2014

    Patients with epilepsy may develop tolerance to CBD-enriched oil
    Jake Remaly, Neurology, 2018
    Perampanel May Decrease Primary Generalized Tonic–Clonic Seizures
    Neurology, 2015
    Perampanel May Decrease Primary Generalized Tonic–Clonic Seizures
    Neurology, 2015
    Carisbamate Shows Antiepileptic Efficacy; Phase III Studies Planned
    Mitchel L. Zoler, Neurology, 2008"

    Looks as though medical cannabis is real!  Its has taken a long time but now it's being look into for true benefits.  No wonder marijuana has stayed around for so many years for both medical and recreational use.  It works!   ;) 
« Last Edit: May 01, 2019, 09:17:12 pm by WhatTheHey »
WhatTheHey

Offline Shasta56

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Re: Medical Cannabis Comes Through
« Reply #1 on: May 08, 2019, 11:02:30 pm »
So it sounds like they're working with actual cannabis, instead of the synthetic formulation that's been around for some years.  I was told by several patients that the synthetic stuff was worthless.  The human brain has receptors for the actual plant stuff.
Daughter of Sekhmet

Offline WhatTheHey

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Re: Medical Cannabis Comes Through
« Reply #2 on: May 09, 2019, 09:53:49 am »
   Yep I agree.  I have heard/read many reports stating that "real" THC/CBD products get better results then synthetic.  In fact I spoke to a chemist friend of mine and he said that it may turnout a combination of both THC and CBD work better the one or the other alone.  At any rate I'm glad to see its being looked into.  ;D   8)
WhatTheHey

 


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